ea0041gp144 | Paediatric Endocrinology & Development | ECE2016
Lopez Ignacio
, Pineda Carmen
, Raya Ana I
, Rodriguez-Ortiz Maria E
, Diaz-Tocados Juan M
, Rios Rafel
, Rodriguez Mariano
, Aguilera-Tejero Escolastico
, Almaden Yolanda
A relationship between obesity, plasma leptin concentration and primary hyperparathyroidism has been previously reported. To test the hypothesis that leptin directly stimulates parathyroid hormone (PTH) secretion, in vivo and in vitro experiments were conducted. In the in vivo studies leptin (200 μg/kg, ip) was administered to lean and obese (mutants that do not express active leptin receptor) Zucker rats. The in vitro experiments were ...